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1. jabiel dice:

   28 de Enero de 2009 a las 16:29

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2. viri dice:

   19 de Febrero de 2009 a las 17:38

   Published online February 16, 2009
   doi:10.1083/jcb.200809077
   The Journal of Cell Biology
   The Rockefeller University Press, 0021-9525 $30.00
   © 2009 Daniels et al.

   ________________________________________REPORT
   Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion

   Brian R. Daniels1, Edward M. Perkins2, Terrence M. Dobrowsky1,3, Sean X. Sun1,3,4, and Denis Wirtz1,3
   1 Department of Chemical and Biomolecular Engineering, 2 Integrated Imaging Center, 3 Howard Hughes Medical Institute Graduate Training Program and Institute for NanoBioTechnology, and 4 Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218
   To generate cellular diversity in developing organisms while simultaneously maintaining the developmental potential of the germline, germ cells must be able to preferentially endow germline daughter cells with a cytoplasmic portion containing specialized cell fate determinants not inherited by somatic cells. In Caenorhabditis elegans, germline inheritance of the protein PIE-1 is accomplished by first asymmetrically localizing the protein to the germplasm before cleavage and subsequently degrading residual levels of the protein in the somatic cytoplasm after cleavage. Despite its critical involvement in cell fate determination, the enrichment of germline determinants remains poorly understood. Here, combining live-cell fluorescence methods and kinetic modeling, we demonstrate that the enrichment process does not involve protein immobilization, intracellular compartmentalization, or localized protein degradation. Instead, our results support a heterogeneous reaction/diffusion model for PIE-1 enrichment in which the diffusion coefficient of PIE-1 is reversibly reduced in the posterior, resulting in a stable protein gradient across the zygote at steady state.
   Abbreviations used in this paper: A/P, anterior/posterior; FCS, fluorescence correlation spectroscopy; ROI, region of interest; UTR, untranslated region.
   © 2009 Daniels et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml).

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